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Pharmaceuticals Injections

Pioneers in the industry, we offer cefotaxime and sulbactum injection, dactinomycin injection, irinotecan injection, leuprolide injection, piroxicam injection and fludarabine injection from India.

Cefotaxime And Sulbactum Injection

Cefotaxime And Sulbactum Injection
  • Cefotaxime And Sulbactum Injection
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Medicine TypeAllopathic
Product TypeFinished Product
UsageCommercial
Usage/ApplicationCommercial

  • It is an anti-infective combination of Cefotaxime and Sulbactam. Cefotaxime is a broad-spectrum semi-synthic third generation cephalosporin with potent bactericidal activity against a wide range of gram-positive and gram-negative bacteria. Sulbactam is beta lactamase inhibitor.
Composition : 500mg 250mg, 1gm 0.5gm
Indications : LRTI, GIT infections.
Dosage :Adult : Mild to moderate : 1g/0.5g to 2g/1g of cefotaxime/sulbactam every 8-12 hours.
Moderate to severe : 1g/0.5g to 2g/1g of cefotaxime/sulbactam every 6-8 hours.
Children : 100/50 to 150/75 mg of cefotaxime/sulbactam per kg b.w. per day in three divided doses.
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Dactinomycin Injection

Dactinomycin Injection
  • Dactinomycin Injection
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UsageCommercial
Form of MedicineInjection

  • Category Anti-neoplastic. Each vial contains Dactinomycin USP 500 mcg. Good evidence exists that this drug bind strongly, but reversibly, to DNA, interfering with synthesis of RNA (prevention of RNA polymerase elongation) and, consequently, with protein synthesis.
Specification-pH range- 5.5 to 7.5
Dactinomycin is a clear, gold-colored liquid given into a vein (IV).
A compound composed of a two cyclic peptides attached to a phenoxazine that is derived from streptomyces parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy.
Indication For treatment of Wilms' tumor, childhood rhabdomyosarcoma, Ewing's sarcoma and metastatic, nonseminomatous testicular cancer as part of a combination chemotherapy and/or multi-modality treatment regimen.
Dosage -Dose intensity per 2-week cycle for adults or children should not exceed 15 mcg/kg/day or 400-600 mcg/m/day intravenously for five days.
Contra Indications-Active infection with chiken pox or herpes zoster (a severe generalized form of disease may occure), infants less than12 months.
Precautions-This drug is not recommended for use during pregnancy. Precaution is advised when using this drug in the elderly because they may be more sensitive to the effects of the drug, especially the effect on blood cell production (myelosuppression).
Drug interaction Trastuzumab may increase the risk of neutropenia and anemia. Monitor closely for signs and symptoms of adverse events.
Adverse effects Nausea, vomiting, malaise, fatigue, cheilitis, dysphagia, bone marrow depression gastric ulceration, hepatitis, hepatomegaly, abnormal liver function, alopecia, skin eruotion.
StoragePowder for injection at room temperature (59 Degree to 86 DegreeF). Protect from light and humidity.
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Irinotecan Injection

Irinotecan Injection
  • Irinotecan Injection
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Form of MedicineInjection
TypeAllopathic

  • Category: Anticancer. Each vial contains:- Irinotecan 40mg/2ml, 100mg/5ml. Specifications: Irinotecan injection is supplied as sterile, pale yellow, clear, aqueous solution. The pH of the solution is in between 3.0 to 3.8.
Composition : Each vial contains:
Irinotecan 40mg/2ml, 100mg/5ml Water for Injection q.s.
Indications : It is indicated as a component of first-line therapy in combination and leucovorin for patients with metastatic carcinoma of the colon or rectum.
It is also indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.
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Contraindications : It is contraindicated in patients with a known hypersensitivity to the drug or its excipients.
Pharmacological action: Irinotecan is a derivative of camptothecin. It interact specifically with the enzyme topoisomerase I which relieves torsional strain in DNA by inducing reversible single-strand breaks. Irinotecan and its active metabolite SN-38 bind to the topoisomerase I-DNA complex and prevent religation of these single-strand breaks.
Adverse Effects : : Abdominal discomfort, diarrhoea, Leukopenia, neutropenia, haemorrhage, body pain, insomania, dizziness, anaemia vomiting, nausea
Dosage : Irinotecam should be administered as an intravenous infusion over 90 minutes for both the weekly and once-every-3-week dosage schedules.
Weekly dose schedule: The usual starting dose is 125 mg/m2. Subsequent doses may be adjusted to as high as 150 mg/m2.
Once every three week schedule: starting dose is 350 mg.m2
Storage: 2-80C
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Leuprolide Injection

Leuprolide Injection
  • Leuprolide Injection
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Form of MedicineInjection
UsageCommercial
TypeAllopathic

  • Category: Anti-neoplastic, Composition- : Each 0.5ml Contains : Leuprolide Acetate 1mg
Specification-pH range – : 5.5 to 6.5
Leuprolide acetate is a synthetic nonapeptide analog of naturally occurring gonadotropin releasing hormone (GnRH or LH-RH). The analog possesses greater potency than the natural hormone. It is a sterile, aqueous solution intended for subcutaneous injection.
Indication :Advanced prostatic carcinoma when orchidectomy or oestrogen administration is not indicated.
Dosage :-SC inj., 1 mg single dose.
Contraindications:-Pregnancy, in women who may become pregnant while receiving the drug, and during lactation. Sensitivity to benzyl alcohol (found in leuprolide injection). Undiagnosed abnormal vaginal bleeding. Hypersensitivity to GnRH/GnRH agonist analogs. The 30-mg depot in women.
Precautions:-Patients with metastatic vertebral lesions and/or with urinary tract obstruction should be closely observed during the first few weeks of therapy. Patients with known allergies to benzyl alcohol, an ingredient of the drug's vehicle, may present symptoms of hypersensitivity, usually local, in the form of erythema and induration at the injection site.
Drug interaction: Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued. Administration of leuprolide acetate in therapeutic doses results in suppression of the pituitary-gonadal system. Normal function is usually restored within 4 to 12 weeks after treatment is discontinued.
Adverse Effect-: High blood pressure, ischemia, insomnia, constipation, urinating more often than usual, bone pain, loss of movement in any part of your body; swelling, rapid weight gain.
Storage:: Store unopened bottles in the refrigerator. Vials can be kept at room temperature (less than 86 degrees F or 30 degrees C). Do not freeze. Protect from light.
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Piroxicam Injection

Piroxicam Injection
  • Piroxicam Injection
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Piroxicam: Its anti- inflammatory potency is similar to indomethacin and analgesic action is greater than aspirin. It has useful antipyretic proerty.
Indications:Its anti- inflammatory potency is similar to indomethacin and analgesic action is greater than aspirin. It has useful antipyretic proerty.
Dosage:Rheumatod arthritis, osteroarthritis, ankylosing, Spondylitis: 20mg daily as single dose. Maint : 10-30 mg .Acute Musculo-skeletal disorders: 40mg in a single or divided doses for 7-14 days. Acute gout : 40 mg as a single dose. Maint : 40 mg in single or divided doses for 4-6 days.
Contra-Indications:Hypersensitivity , pregnancy children patients who develop asthama or allergy with other inflammatory drugs, lactation.
Special Precautions:Renal or hepatic dysfunction, asthma surgery, haemorrhagic disorders. Hypertension. Cardiovascular disease.
Paediatrics: Not recommended in age below 6 yrs.
Pregnancy:Contraindicated may affect the foetus.
Lactation:Safety not established.
Elderly:Reduced dose necessary.
Side Effects: Heart burn, nausea, anorexia, rashes, pruritus, C.N.S. manifestations. Oedema.
Drug Interactions: Potentiate anticoagulants. Diuretics increase risk of renal damage. Monitor lithium levels. Aspirin reduces serum levels.
Purity :Not less than 99%.
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Fludarabine Injection

Fludarabine Injection
  • Fludarabine Injection
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  • Category: Anti-neoplastic. Composition- : Each lyophilized vial contains :- Fludarabin - 50 mg, Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Specification-pH: 6.0 ­ 7.1
Indication :Fludarabine is primarily indicated in conditions like Chronic lymphocytic leukaemia,Lymphoid malgnancies, and can also be given in adjunctive therapy as an alternative drug of choice in Acute leukemia, Indolent lymphoma, Myclodysplastic syndrome, Myelodysplastic syndrome, Myeloid leukaemia.
Dosage :-The recommended adult dose of fludarabine for injection is 25 mg/m² administered intravenously over a period of approximately 30 minutes daily for five consecutive days. Each 5 day course of treatment should commence every 28 days.
Contra Indications:-Fludarabine is contraindicated in conditions like Peripheral neuropathy, HIV infection, Renal impairment, Central neuropathy.
Precautions:-During/after treatment with fludarabine for injection, vaccination with live vaccines should be avoided. If it is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.
Drug interaction: The use of Fludarabin for injection in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.
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Fludarabine Injection

Fludarabine Injection
  • Fludarabine Injection
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Product Details:

Usage/ApplicationCommercial
Product TypeFinished Product

  • Category: Anti-neoplastic
Each lyophilized vial contains:- Fludarabin 50 mg
Fludarabine phosphate is rapidly dephosphorylated to 2-fluoro-ara-A and then phosphorylated intracellularly by deoxycytidine kinase to the active triphosphate, 2-fluoro-ara-ATP. This metabolite appears to act by inhibiting DNA polymerase alpha, ribonucleotide reductase and DNA primase, thus inhibiting DNA synthesis. The mechanism of action of this antimetabolite is not completely characterized and may be multi-faceted.
Specification-pH: 6.0 ­ 7.1
Indication :Fludarabine is primarily indicated in conditions like Chronic lymphocytic leukaemia,Lymphoid malgnancies, and can also be given in adjunctive therapy as an alternative drug of choice in Acute leukemia, Indolent lymphoma, Myclodysplastic syndrome, Myelodysplastic syndrome, Myeloid leukaemia.
Dosage :-The recommended adult dose of fludarabine for injection is 25 mg/m² administered intravenously over period of approximately 30 minutes daily for five consecutive days. Each 5 day course of treatment should commence every 28 days.
Contra Indications:-Fludarabine is contraindicated in conditions like Peripheral neuropathy, HIV infection, Renal impairment, Central neuropathy.
Precautions:-During and after treatment with fludarabine for injection, vaccination with live vaccines should be avoided. If it is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant.
Drug interaction: The use of Fludarabin for injection in combination with pentostatin is not recommended due to the risk of severe pulmonary toxicity.
Storage:Store in refrigerator. Use within 8 hrs if kept at room temperature.
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